Introduction . Genomic DNA damage and subsequent mutation and selection is not only a driver of evolution but also of oncogenesis, as it can result in the acquisition of the Hallmarks of Cancer1. A tight control of genome integrity is therefore required to suppress malignant cell growth. The cellular DNA damage response (DDR), for instance, triggers a temporary cell cycle arrest to repair damaged DNA. Persistent DNA damage induces apoptosis or a permanent withdrawal from the cell c...